Antibody-dependent enhancement (ADE) in Covid-19 physiopathology, a cross-model single-cell RNA-seq perspective
2023
Olivier, Thibaut | Desmecht, Daniel
Cytokine storm is considered a driving factor of COVID-19 severity. However, the triggering and resolution of this cytokine production as well as the link between this phenomenon and infected cells is still poorly understood. Considering that M1 macrophages are specialized for pathogen killing and secrete pro-inflammatory cytokines as well as chemokines upon Ifn-γ activation, an assessment of their contributions in cytokine storms is necessary. Moreover, considering that Fc receptors for immunoglobulin G (FcγR) expression was found to be stimulated by Ifn-γ in monocytes and macrophages and that FcγR markedly affect antigen uptake in macrophages, exploring the potential link between FcγR-mediated antibody-dependent infections of M1 macrophages and the surge of cytokine storms caused by SARS-CoV-2 infections constitutes a promising avenue of research to explain the phenomenon of antibody-dependent enhancement (ADE).
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