Secretome of animal trypanosomes from a standard method toward new diagnostic and therapeutic targets
2007
Holzmuller, P. | Grébaut, P. | Peltier, Jean Benoît | Brizard, J.P. | Perrone, T. | Gonzatti, M. | Bengaly, Z. | Rossignol, Michel | Aso, P.M. | Vincendeau, P. | Cuny, G. | Boulangé, A. | Frutos, R. | Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Unité de Recherche Protéomique (PROTEOMIQUE) ; Institut National de la Recherche Agronomique (INRA) | Institut de Recherche pour le Développement (IRD) | Instituto Venezolano de Investigaciones Cientificas (IVIC) | Universidad Simon Bolivar (USB) | Centre international de recherche-développement sur l'élevage en zone sub-humide (CIRDES) | Laboratoire de Parasitologie (EA 3677) ; Université Bordeaux Segalen - Bordeaux 2 | Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides (UMR INTERTRYP) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Université de Bordeaux (UB)
International audience
Mostrar más [+] Menos [-]Inglés. Animal trypanosomosis is one of the most severe constraints to agricultural development in sub-Saharan Africa and is also an important disease of livestock in Latin America and Asia. The causative agents are various species of protozoan parasites belonging to the genus Trypanosoma, among which T. congolense and T. evansi are the major pathogenic species. The extracellular position of trypanosomes obliges us to consider both the parasite and its excreted/secreted factors in the course of the physiopathologic process. The advent of proteomics led us to propose a comparative approach of the proteome (i.e., the whole parasite content) and the secretome (i.e., naturally excreted/secreted molecules) of T. congolense and T. evansi with particular attention to common and specific molecules between strains of differing virulence and pathogenicity. The molecular identification of differentially expressed trypanosome molecules correlated with either the virulence process or the pathogenicity will provide new potential molecular targets for improved field diagnosis and chemotherapy of animal trypanosomosis
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Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique