Genes and evolutionary fates of the amanitin biosynthesis pathway in poisonous mushrooms
2022
Luo, Hong | Hallen-Adams, Heather | Lüli, Yunjiao | Sgambelluri, R. Michael | Li, Xuan | Smith, Miranda | Yang, Zhu | Martin, Francis | Chinese Academy of Agricultural Sciences (CAAS) | University of Nebraska–Lincoln ; University of Nebraska System | Michigan State University System | Kunming University of Science and Technology (KMUST) | Interactions Arbres-Microorganismes (IAM) ; Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Significance Why do unrelated poisonous mushrooms ( Amanita , Galerina , and Lepiota ) make the same deadly toxin, α-amanitin? One of the most effective and fast strategies for organisms to acquire new abilities is through horizontal gene transfer (HGT). With the help of genome sequencing and the finding of two genes for the amanitin biosynthetic pathway, we demonstrate that the pathway distribution resulted from HGT probably through an unknown ancestral fungal donor. In Amanita mushrooms, the pathway evolved, through a series of gene manipulations, to produce very high levels of toxins, generating “the deadliest mushroom known to mankind.”
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique