Terbufos sulfone aggravates kidney damage in STZ-induced diabetic rats
2017
Nurulain, Syed Muhammad | Ojha, Shreesh | Shafiullah, Mohamed | Yasin, Javed | Yasmin, Tayyaba | Saeed, Tariq | Adeghate, Ernest
The consequences of chronic exposure of organophosphorus compounds (OPCs) on diabetic subjects have been seldom reported. The aim of the present study was to assess the impact of non-lethal dose of terbufos sulfone (TS), an organophosphate, on the kidney of non-diabetic and streptozotocin (STZ)- induced diabetic rats. The diabetogenic effect of TS was also examined. Male Wistar rats were treated for two weeks with 130 µg/kg body weight/day of TS. This dose was 1/20 of LD₅₀ and produces less than 10% inhibition of acetylcholinesterase (AChE) in non-diabetic rats. No observable symptoms of poisoning were noted. Weight, glucose and in vivo red blood cell (RBC)-AChE were measured on day 7 and 15 of the study. Serum biochemistry, urine analysis, and transmission electron microscopy (TEM) of kidney were performed to assess the toxicity at the end of the 15-day study. Our results did not reveal diabetogenic effect of TS treatment. Blood glucose level was significantly increased and RBC-AChE activity was significantly decreased in diabetic-TS treated rats compared to untreated diabetic and normal control animals. TEM of kidney revealed structural damage to kidney, which was more severe in diabetic-TS treated rats compared to controls. Toxicity to kidney by TS was further confirmed by urine and blood biochemistry. Our results conclude that non-lethal dose of TS aggravates the nephrotoxicity in diabetic rats. Further studies with other OPCs are needed to be able to generalize the diabetogenic effect of TS.
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