Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF₁) receptor antagonists
2012
Saito, Tetsuji | Obitsu, Tetsuo | Kohno, Hiroshi | Sugimoto, Isamu | Matsushita, Takeshi | Nishiyama, Taihei | Hirota, Tomoko | Takeda, Hiroyuki | Matsumura, Naoya | Ueno, Sonoko | Kishi, Akihiro | Kagamiishi, Yoshifumi | Nakai, Hisao | Takaoka, Yoshikazu
To identify structurally novel corticotropin-releasing factor 1 (CRF₁) receptor antagonists, a series of bicyclic core analogs pyrrolo[1,2-b]pyridazines and pyrrolo[2,1-f]triazin-4(3H)-ones, which were designed based on a monocyclic core antagonist, was synthesized and evaluated. Among the compounds tested, 2-difluoromethoxy-4-methylpyridin-5-yl analog 27 was found to show efficacy in a dose-dependent manner in an elevated plus maze test in rats. The discovery process and structure–activity relationship is presented.
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