Effect of n‐3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus
2003
Nesbitt, Gene H. | Freeman, Lisa M. | Hannah, Steven S.
The use of n‐3 fatty acids is often recommended to manage pruritus. The purpose of this study was to determine the effect of various doses of n‐3 fatty acids at different n‐6:n‐3 ratios on plasma fatty acids, clinical response and inflammatory mediators in pruritic dogs. After baseline assessment, dogs were randomly assigned to receive diets varying in both total n‐3 and n‐6 fatty acid dose and n‐6:n‐3 ratio. The total clinical score decreased significantly in all four diet groups after 8 weeks with no difference between groups. Plasma fatty acid changes generally mirrored the fatty acid content of the test diets, although alterations appeared to depend on both the dose of n‐3 fatty acids and the n‐6:n‐3 ratio. In this clinical trial, which controlled dietary intake of fatty acids, n‐3 fatty acid supplementation did not appear to have an added benefit on clinical signs over thorough clinical management.
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