Protocol for synthesis of di- and tri-substituted s-triazine derivatives
2020
El-Faham, Ayman | Sharma, Anamika | Fārūq, Muḥammad | Almarhoon, Zainab | Alhameed, Rakia Abd | Wadaan, Mohammad A.M. | de la Torre, Beatriz G. | Albericio, Fernando
The present protocol describes the synthesis of di and tri-substituted s-triazine derivatives•s-Triazine undergoes sequential nucleophilic substitution reaction but order of nucleophile is very crucial.•It is very difficult to substitute any nucleophile except amine once amine is incorporated onto s-triazine.•During the synthesis of O,N-type substituted s-triazine, always O-type should be incorporated first.
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