A Three-Component Reaction for the Synthesis of 1-Azabicyclo[3.1.0]hexane-3-enes
2016
Ghorbani, Mahdi | Mohammadi, Bagher | Saraii, Mahnaz | Masoumi, Bakhshali | Abbasian, Mojtaba | Ramazani, Ali | Slepokura, Katarzyna | Lis, Tadeusz
A novel and simple synthesis of 1-azabicyclo[3.1.0]hexane-3-ene derivatives is described. The synthesis is carried out via a simple three-component reaction between aryl aldehydes, malononitrile, and hydroxylamine hydrochloride in water. Eco-friendliness, excellent product yields, short reaction time, inexpensive and readily available starting materials, and interesting reaction and products are the main advantages of this method.
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