Effect of changes in ionized calcium concentration in arterial blood and metabolic acidosis on the arterial partial pressure of oxygen in dogs
2006
Lopez, I. | Felsenfeld, A.J. | Estepa, J.C. | Rodriguez, M. | Aguilera-Tejero, E.
Objective-To evaluate the effects of metabolic acidosis and changes in ionized calcium (Ca(2+)) concentration on Pao2 in dogs. Animals-33 anesthetized dogs receiving assisted ventilation. Procedure-Normal acid-base status was maintained in 8 dogs (group I), and metabolic acidosis was induced in 25 dogs. For 60 minutes, normocalcemia was maintained in group I and 10 other dogs (group II), and 10 dogs were allowed to become hypercalcemic (group III); hypocalcemia was then induced in groups I and II. Groups II and IV (5 dogs) were treated identically except that, at 90 minutes, the latter underwent parathyroidectomy. At intervals, variables including Pao2, Ca(2+) concentration, arterial blood pH (pHa), and systolic blood pressure were assessed. Results-In group II, Pao2 increased from baseline value (96 +/- 2 mm Hg) within 10 minutes (pHa, 7.33 +/- 0.001); at 60 minutes (pHa, 7.21 +/- 0.02), Pao2 was 108 +/- 2 mm Hg. For the same pHa decrease, the Pao2 increase was less in group III. In group I, hypocalcemia caused Pao2 to progressively increase (from 95 +/- 2 mm Hg to 104 +/- 3 mm Hg), which correlated (r = -0.66) significantly with a decrease in systolic blood pressure (from 156 +/- 9 mm Hg to 118 +/- 10 mm Hg). Parathyroidectomy did not alter Pao2 values. Conclusions and Clinical Relevance-Induction of hypocalcemia and metabolic acidosis each increased Pao2 in anesthetized dogs, whereas acidosis-induced hypercalcemia attenuated that increase. In anesthetized dogs, development of metabolic acidosis or hypocalcemia is likely to affect ventilatory control.
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