Effect of oral methionine on tissue lipid peroxidation and antioxidants in alloxan-induced diabetic rats
1993
Anuradha, C.V. | Celvam, Irā
Supplementation of thiol compounds has been suggested to protect against the toxic effects of reduced oxygen species by contributing to the thiol pool of the cell. The present study was designed to determine whether supplementation of methionine in the diet of diabetic animals protected against the oxidative stress in diabetic pathology. Oral methionine was administered at a dosage of 330 mg/100 g feed to diabetic rats. The effect was compared with the effect of insulin administration. Levels of lipid peroxides and antioxidants were measured in liver, kidney, and pancreas. A diabetic condition was associated with increased lipid peroxidation and depletion in antioxidants levels. Methionine did not lower the lipid peroxide content or the release of lipid peroxides from tissues in presence of promoters or restore the levels of alpha-tocopherol and ascorbic acid in tissues. Administration of insulin lowered the tissue lipid peroxide levels and restored the antioxidants levels.
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