Synthesis of functionalized 2-isoxazolines as three-dimensional fragments for fragment-based drug discovery
2015
Trần, Ngọc Châu | Dhondt, Heleen | Flipo, Marion | Deprez, Benoit | Willand, Nicolas
The design of new sp³ and spiro-enriched fragments has been achieved from 1,3-dipolar cycloaddition between alkenes and chloro-oximes. The selection of reagents was performed to afford a panel of 2-isoxazoline-containing fragments that show desirable three dimensional (3D) characteristics to allow the probing of biologically-relevant chemical space. Principal moments of inertia (PMI) were calculated to evaluate the 3D diversity. The resulting 3D fragments with suitable physicochemical properties, especially a good solubility, will be used to improve the hit rate of our fragment-based screening.
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