New Bicyclo[3.1.0]hexane Unit ent-Kaurane Diterpene and Its seco-Derivative from Isodon eriocalyx var. laxiflora
2012
Wang, Wei-Guang | Du, Xue | Li, Xiao-Nian | Wu, Hai-Yan | Liu, Xu | Shang, Shan-Zhai | Zhan, Rui | Liang, Cheng-Qin | Kong, Ling-Mei | Li, Yan | Pu, Jian-Xin | Sun, Han-Dong
Neolaxiflorin A (1), an unprecedented ent-kaurane diterpenoid with a bicyclo[3.1.0]hexane unit, and its seco-derivative, neolaxiflorin B (2), along with two known compounds 3 and 4 were isolated from the leaves of Isodon eriocalyx var. laxiflora. The absolute configuration of 1 was determined by spectral methods and single crystal X-ray diffraction analysis. Compound 4 and the synthesized compound 5 exhibited significant cytotoxicity.
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