Radiation-Induced Degradation of Purine and Pyrimidine 2′-Deoxyribonucleosides in Aqueous KBr Solutions
2014
Cadet, J. | Voituriez, L. | Berger, M. | Myers, L. S.
Steady-state γ-radiolysis of 5 × 10⁻⁴ M pyrimidine and purine 2′-deoxyribonucleosides in aqueous solutions saturated with N₂, N₂O and O₂, respectively, have been carried out in the presence of 0.1 M KBr. The main final degradation products have been isolated and characterised by various spectroscopic measurements including ¹H and ¹³C NMR, UV, C.D. and mass spectrometry. The radiation-induced decomposition of thymidine is mostly accounted for by an ionic mechanism involving Br₂, the decay product of Br₂-·, as the reactive oxidising specie. On the other hand the degradation of the purine ring of 2′-deoxy-adenosine and 2′-deoxyguanosine may be accounted for by the action of Br₂-·or Br₃·²⁻
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