Isolation and identification of oxygenated lanostane-type triterpenoids from the fungus Ganoderma lucidum
2016
Zhao, Xi-Run | Zhang, Bao-Jing | Deng, Sa | Zhang, Hou-Li | Huang, Shan-Shan | Huo, Xiao-Kui | Wang, Chao | Liu, Fang | Ma, Xiao-Chi
Ganoderma lucidum is widely used throughout the world as a form of traditional medicine. Phytochemical investigation of the chloroform (CHCl3) extract of the fruiting body of G. lucidum resulted in the isolation of four lanostane-type triterpenoids. Based on various spectroscopic data, the isolated triterpenoids were identified as highly oxygenated lanostane-type triterpenoids, including four new compounds (1–4). Furthermore, in vitro bioassays using an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and measuring the nitric oxide production in LPS-stimulated macrophages showed that the isolated triterpenoids had no inhibitory effects on p-glycoprotein (p-gp).
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