Correlation between serum insulin-like growth factor 1 (IGF) concentrations and nutritional status in HIV-infected individuals
1995
Salbe, A.D. | Kotler, D.P. | Tierney, A.R. | Wang, J. | Pierson, R.N. Jr | Campbell, R.G.
The usefulness of serum insulin-like growth factor 1(IGF1) determinations as an estimate of nutritional status in HIV-infected individuals is unclear. Serum IGF1 levels were correlated with measurements of total body potassium (TBK), a measure of body cell mass, and changes in TBK in 32 subjects including 18 AIDS patients, 4 HIV seronegative and 5 seropositive asymptomatic homosexual male controls, and 5 HIV seronegative heterosexual controls. Longitudinal follow-up of body composition including measurements of TBK, body fat content, serum IGF1, and albumin concentrations was determined in the AIDS group and in demonstrated subgroups of AIDS patients with progressive depletion, stable body composition, and those undergoing repletion. IGF1 levels correlated with serum albumin levels (r=0.66, p<0.001), and with body cell mass as normalized TBK/height (r=0.55, p<0.001). IGF1 levels were lower in the AIDS groups than in the control groups (p<0.05), and differed among the subgroups of AIDS patients: repleting patients had higher concentrations than stable or depleting patients. IGF1 levels may be a convenient way to predict the course of nutritional status in an HIV-infected individual.
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