Activation of the expression of two immunoglobulin CH genes of the American mink during Aleutian disease
1991
Fomicheva, I.I. | Tsertsvadze, D.K. | Volkova, O.Yu | Popova, N.A. | Smirnykh, S.I. | Kisteneva, N.A. | Kuznetsov, K.N. | Kudashev, V.F. | Kaveshnikov, Yu.D.
The genetic allotypic polymorphism of immunoglobulins secreted by mink after infection with Aleutian disease virus (plasmocytosis) was investigated. It was shown that the expression of two of the four allotypes of the constant region of the gamma-heavy chain, which is considered stable throughout ontogenesis, is sharply activated in most of the infected mink. Such allotype-specific regulation of the expression of the immunoglobulin CH genes may also occur in the immune response in humans, where many data have been accumulated on the association of individual Gm-allotypes with a whole series of diseases.
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