Atalantums H-K from the peels of Atalantia monophylla and their cytotoxicity
2020
Sombatsri, Aonnicha | Thummanant, Yutthapong | Sribuhom, Thurdpong | Wongphakham, Paweena | Senawong, Thanaset | Yenjai, Chavi
Four new benzoyltyramines, atalantums H-K (1–4) and seven known compounds were isolated from the peels of Atalantia monophylla. All compounds were tested for cytotoxicity against HeLa, HCT116 and MCF-7 cell lines, as well as normal cells (Vero cells). Compound 5 showed cytotoxicity against HeLa, HCT116 and MCF-7 cell lines with IC₅₀ values ranging from 16-25 μg/mL but was inactive against Vero cells. Compound 6 also showed interesting results as compound 5 with IC₅₀ values ranging from 15-18 μg/mL and an IC₅₀ value of 80.20 μg/mL against Vero cells. This means compounds 5 and 6 can be used as lead compounds for anticancer agents.
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