Genetic epidemiology, association, and sib-pair linkage: results from the Quebec Family Study
1996
Bouchard, C.
The Quebec Family Study has been in progress for about fifteen years. It was initially based on a panel of 375 families, which included several types of relatives by descent or adoption (Phase 1). A subsample of about 100 families from Phase 1 plus a panel of 40 families with obese probands are incorporated in Phase 2. Those families will be remeasured every five years for a panel of body-fat, regional fat distribution, and metabolic phenotypes. The results from several genetic epidemiology studies reveal that heritability of body-fat content attains about 25%. Studies have also indicated that an autosomal recessive gene could potentially contribute to variation in body fat in the Quebec Family Study Phase 1 cohort. Association and linkage studies with candidate genes and other markers reveal that it is useful to take into account both total body fat and fat distribution phenotypes. The first few reports suggest that a good number of genes and chromosomal regions need to be considered in the investigation of the genetic architecture of body-fat content and subcutaneous fat distribution.
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