10trans, 12cis-Linoleic acid reduces apolipoprotein B secretion in HepG2 cells
1998
Yotsumoto, H. | Hara, E. | Naka, S. | Adlof, R.O. | Emken, E.A. | Yanagita, T.
The effects of conjugated linoleic acids (9cis, 11cis-linoleic acid and 10trans, 12cis-linoleic acid) and 9cis, 12cis-linoleic acid on apolipoprotein B (apoB) secretion and on the synthesis of triglycerides and cholesterol were assessed in HepG2 cells. ApoB secretion by cells treated with 10 micromolar 10trans, 12cis-linoleic acid for 24 h was decreased markedly when compared with that by cells exposed to 9cis, 12cis-linoleic acid, while cells treated with 9cis, 11cis-linoleic acid were not affected. 10trans, 12cis-linoleic acid inhibited cellular triglyceride and cholesteryl ester synthesis, but 9cis, 11cis-linoleic acid had no effect on triglyceride synthesis. The present study showed that the two conjugated linoleic acids had different influences on apoB and lipid metabolism. Compared with 9cis, 12cis-linoleic acid, 10trans, 12cis-linoleic acid inhibited cellular triglyceride synthesis and reduced apoB secretion.
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