Induced production of a new polyketide in Penicillium sp. HS-11 by chemical epigenetic manipulation
2021
Ying, You-Min | Li, Ling | Yu, Hang-Fei | Xu, Yi-Lian | Huang, Lu | Mao, Wei | Tong, Cui-Ping | Zhang, Zhi-Dong | Zhan, Zha-Jun | Zhang, Yun
Chemical investigation into the culture broth of the plant endophyte Penicillium sp. HS-11 in the modified Martin’s medium supplemented with subemylanilide hydroxamic acid (SAHA), a well-known histone deacetylase (HDACs) inhibitor, led to the isolation and identification of two induced products 4-epipenicillone B (1) and (R)-(+)-chrysogine (2). 4-epipenicillone B (1) was obtained as a new compound whose structure was elucidated by comprehensive spectroscopic methods including 1 D/2D NMR, HRESMS, and quantum chemistry calculations including DFT GIAO ¹³C NMR and ECD calculation. Acquisition of 4-epipenicillone B (1) enriched the chemical diversities of fungal natural products possessing a tricyclo [5.3.1.0³,⁸] undecane skeleton. The cytotoxic activity of 1 was also evaluated.
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