Adipose tissue cellularity: A review. 2. The relationship between cellularity and obesity
1979
Kirtland, Janet | Gurr, Michael I.
The "fat cell hypothesis" is that overfeeding in early life stimulates the formation of excess fat cells and thereby more readily predisposes the individual to obesity in later life. Evidence for the hypothesis is reviewed. The reliability of fat cell number data is discussed. Possible metabolic consequences of altered cellularity and distinctions between hyperplastic and hypertrophic obesity are examined. There is cause for concern about current feeding practices that tend to result in overfeeding, but the sequence of events implied by the fat cell hypothesis is unlikely. Extensive references are cited.
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