Association of an oral formulation of angiotensin-(1–7) with atenolol improves lipid metabolism in hypertensive rats
2013
Santos, Cynthia F.F. | Santos, Sérgio H.S. | Ferreira, Adaliene V.M. | Botion, Leida M. | Santos, Robson A.S. | Campagnole-Santos, Maria Jose
The β-adrenergic blockers and antagonists of the renin-angiotensin system (RAS) are among the drugs that present better results in the control of cardio-metabolic diseases. The aim of the present study was to evaluate the effect of the association of the β-blocker, atenolol, and an oral formulation of Ang-(1–7) on lipid metabolism in spontaneously hypertensive rats (SHR). The main results showed that SHR treated with oral formulation of Ang-(1–7) in combination to atenolol have an improvement of lipid metabolism with a reduction of total plasma cholesterol, improvement of oral fat load tolerance and an increase in the lipolytic response stimulated by the β-adrenergic agonist, isoproterenol, without modification of resting glucose or insulin sensitivity in adipocytes. In conclusion, we showed that administration of an Ang-(1–7) oral formulation in association with a β-blocker induces beneficial effects on dyslipidemia treatment associated with hypertension.
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