Calcium permeability and ATPase activities of red blood cells of magnesium deficient rats
1994
Rock, E. | Gueux, E. | Cubizolles, C. | Rayssiguier, Y.
Decreased intracellular magnesium and potassium and increased sodium levels were shown in the erythrocytes of weanling rats fed a low magnesium diet for 8 days. Magnesium-dependent ATPase activity was significantly increased in membranes obtained from Mg-deficient cells and the (Ca2+)- and (Na+ + K+)-stimulated activities were similar to control values. Calcium flux measurements clearly show that passive permeability was significantly increased in red blood cells from Mg-deficient rats. Moreover, initial rates of calcium influx and to a lesser degree calcium efflux were increased in ghosts prepared from Mg-deficient erythrocytes. In agreement with our previous findings on the physical-chemical parameters of these membranes, the present results strongly suggest that permeability properties rather than the pump activities are primarily affected by dietary magnesium deficiency.
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