Graphene quantum dot-decorated mesoporous silica nanoparticles for high aspirin loading capacity and its pH-triggered release
2016
Huang, Shaping | Song, Liping | Xiao, Zhidong | Hu, Yue | Peng, Meiwen | Li, Jinquan | Zheng, Xinsheng | Wu, Bin | Yuan, Chao
In this paper, fluorescent graphene quantum dots (GQDs) grafted onto the surface of mesoporous silica nanoparticle (MSN) vehicles were prepared and characterized. The as-prepared graphene quantum dot-decorated mesoporous silica nanoparticles (GQD-MSNs) exhibited excellent luminescence properties in vitro. Interestingly, compared to pure MSNs, the specific surface area and pore volume of GQD-MSNs increased by 59.1% and 48.9%, respectively. These optimized features granted GQD-MSNs a high aspirin loading capacity, which was twice as much as that of pure MSN. Moreover, most of the aspirin encapsulated (95.15%) could be released from the surface of GQD-MSNs under acidic conditions (pH 2.5) within 33 h.
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