Aflatoxin and liver cancer in Sudan
1998
Omer, R.E. | Bakker, M.I. | Veer, P. van 't | Hoogenboom, R.L.A.P. | Polman, T.H.G. | Alink, G.M. | Idris, M.O. | Kadaru, A.M.Y. | Kok, F.J.
This study investigated whether aflatoxin contamination of peanut products may contribute to the incidence of hepatocellular carcinoma (HCC) in Sudan. Thirty-seven peanut butter and peanut samples were collected from local markets. Aflatoxin concentrations were significantly higher in West Sudan [87.4 +/- 197.3 (SD) microgram/kg], a high-risk area, than in Central Sudan (8.5 +/- 6.8 microgram/kg), a low-risk area. In West Sudan, humid local storage conditions of peanut products were related to high aflatoxin concentrations. In a small case-control study of HCC patients (n = 24) and controls (n = 34). an odds ratio of 7.5 (95% confidence interval = 1.4-40.2) was observed for humid vs. dry local storage conditions. Development of an index of individual HCC exposure was less successful, probably because of year-to-year variability in aflatoxins in food. These preliminary findings justify further research into the role of aflatoxins and hepatitis in HCC incidence in Sudan.
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