Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus
2012
Li, Ning | Zhang, Jia-Yu | Zeng, Ke-Wu | Zhang, Liang | Che, Yan-Yun | Tu, Peng-Fei
Two new homoisoflavonoids, named ophiopogonone E (1) and ophiopogonanone H (2), together with thirteen known ones (3–15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analyses. Compounds 7 and 15 were isolated from the genus for the first time. In addition, compounds 2–15 were evaluated for their effects on the inhibition of NO production induced by lipopolysaccharide in the murine microglial cell line BV-2. Compounds 2, 4, 6, 7, 10, 11 showed potent inhibitory effects on NO production with IC₅₀ values of 20.1, 17.0, 7.8, 5.1, 19.2 and 14.4μM respectively.
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