Effect of phlorotannins from Sargassum thunbergii on blood lipids regulation in mice with high-fat diet
2012
Wei, Yuxi | Xu, Chuanjin | Liu, Qi | Xiao, Huihui | Zhao, Aiyun | Hu, Yingfen | Liu, Lei | Zhao, Ling
On the basis of activity screening on blood lipid regulation by animal study, we chose high molecular weight phlorotannins from Sargassum thunbergii (HMPs) as a drug to explore the regulating mechanism. The results showed that HMPs could significantly decrease TC and TG levels (p < 0.05), and very significantly decrease LDL-C level (p < 0.01). Results of a hypocholesterolemic mechanism study showed that HMPs could obviously increase liver LDL-R level (p < 0.05), but the fact that they failed to block the synthesis of HMG-CoA reductase excludes a relevant influence on cellular cholesterol biosynthesis. We propose that HMPs from Sargassum thunbergii have a profound hypocholesterolemic effect and the mechanism relies mainly on the increase of LDL-R level in liver.
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