Occidiofungin's Chemical Stability and In Vitro Potency against Candida Species
2012
Ellis, Dayna | Gosai, Jiten | Emrick, Charles | Heintz, Rachel | Romans, Lanette | Gordon, Donna | Lu, Shi-En | Austin, Frank | Smith, Leif
Occidiofungin is a cyclic glyco-lipopeptide produced by Burkholderia contaminans. MICs against Candida species were between 0.5 and 2.0 μg/ml. Occidiofungin retains its in vitro potency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 μg/ml, respectively. Time-kill and postantifungal effect (PAFE) experiments of occidiofungin against Candida albicans were performed. The results demonstrate that occidiofungin is fungicidal. Occidiofungin was also found to be a very stable molecule. It is resistant to extreme temperatures and pH and maintains its activity following exposure to gastric proteases.
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