Use of high-performance liquid chromatography coupled with high-resolution mass spectrometry for the identification and quantitative determination of tetrodotoxin in pharmaceuticals
2017
Shalabai, V. V. | Taranchenko, V. F. | Rybal’chenko, I. V. | Aksenov, A. V. | Antokhin, A. M. | Semchenko, F. M. | Krymchak, M. S.
A procedure is developed for the identification and determination of tetrodotoxin in pharmaceuticals by liquid chromatography coupled with high resolution mass spectrometry (HPLC−HRMS). The components of a pharmaceutical sample were separated in the gradient elution mode on a HILIC hydrophilic sorbent and detected by HRMS with electrospray ionization in the mode of registration of selected ion transitions. The calibration curve is linear in the range 0.75−1.25 μg/mL with the correlation coefficient > 0.9995.
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