A convenient one-pot access to phenanthridinones via Suzuki–Miyaura cross-coupling reaction
2013
Tanimoto, Kouichi | Nakagawa, Naomichi | Takeda, Kazutaka | Kirihata, Mitsunori | Tanimori, Shinji
A convenient one-step access to biologically important phenanthridinones 1 has been realized based upon Suzuki–Miyaura cross-coupling reaction. Reactions of 2-aminophenylboronic acid 2 with 2-halobenzoate 3 took place smoothly to afford substituted phenanthridinones 1 in excellent yields in the presence of palladium(II) acetate and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (SPhos) as pre-catalysts. A natural product phenaglydon 1b was synthesized in one-pot manner from readily available starting materials in 95% yield.
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