Antibiofilm phenylethanoid glycosides from Penstemon centranthifolius
2010
Ye, Miao | Zhao, Yun | Norman, Vanessa L. | Starks, Courtney M. | Rice, Stephanie M. | Goering, Matt G. | O'Neil-Johnson, Mark | Eldridge, Gary R. | Hu, Jin-Feng
Bioassay-guided fractionation of the antibacterial ethyl acetate-ethanol (50 : 50) extract obtained from the aerial parts of Penstemon centranthifolius led to the isolation of six phenylethanoid glycosides (1-6) and eleven iridoid glycosides (7-17). Their structures were determined on the basis of spectroscopic analysis and comparison with the literature. Among them, two phenylethanoid glycosides, 4″′-O-acetylverbascoside (1) and verbascoside (2), were found to show significant inhibition of the formation of bacterial biofilms by Escherichia coli UTI89. Compound 1 showed 77% biofilm inhibition at 2.5 μg/mL, and compound 2 showed 60% inhibition at 5 μg/mL.
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