Molecular epidemiological update of Peste des Petits Ruminants virus (PPRV) in Ethiopia
2019
Rume, Veronica Nwankpa | Dundon, William G. | Belay, Gurja | Baziki, Jean-de-Dieu | Diakite, Adama | Paul, Ankeli | Tessema, Yebchaye Degefa | Nwankpa, Nick | Dāneʼél Gezāw, | Cattoli, Giovanni | Bodjo, Sanne Charles | Tessema, Tesfaye Sisay
Peste des Petits ruminants (PPR) is a devastating disease of small ruminants with high morbidity and mortality rates among susceptible animals. The disease is endemic in much of Africa, the Middle East and Asia and constitutes one of the major hurdles to the improvement of small-ruminant production in these countries. The causal agent of PPR, the Small Ruminant Morbillivirus (SRMV), previously known as PPR virus (PPRV) belongs to the genus Morbillivirus within the family Paramyxoviridae. SRMV can be categorized into four genetically distinct lineages (I to IV). Suspicion of PPR was first reported in Ethiopia in 1977 and since then genetic characterization of circulating viruses has identified lineages III and IV in the country. This study was undertaken to provide an update on the molecular epidemiology of PPR in Ethiopia by analysing animal tissue samples collected between 2011 and 2017. PPR positive samples were identified in four regions of the country. Sequence and phylogenetic analysis of fourteen RT-PCR positive amplicons revealed that all of the SRMV in the samples from 2010 to 2017 belong to sub-clade II of clade I of lineage IV. No lineage III viruses were identified.
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