Phosphatidylmannoside prevents obesity induced by high-fat feeding
2022
Liu, Yanjun | Li, Ziwei | Liu, Junyi | Xu, Jie | Liu, Yuanfa | Xue, Changhu
Emerging evidence suggests that dietary d-mannose, enriched naturally in many plants and fruits, show benefits in patients with bacterial urinary tract infection, diabetes, and obesity. However, it is noteworthy that the physiological level of d-mannose in the blood is relatively low. Based on the study that d-mannose could be a safe and beneficial dietary supplement to obese, here phosphatidylation of mannose was proposed as a way to increase the physiological level of d-mannose and enhance the modulatory effect of mannose on obesity. In this study, phosphatidylmannoside (PtdMan) was synthesized via the approach of phospholipase D mediated transphosphatidylation. In vivo, we show that phosphatidylation of mannose enhanced the physiological level of mannose in blood. The benefits of PtdMan and d-mannose in high-fat diet-induced obesity were then investigated. Compared with d-mannose supplementary, increased physiological level of PtdMan enhanced the expression of fatty acid oxidation-related genes in liver and PPARγ targeted genes in adipose tissue, thus protecting from high-fat diet induced obesity, glucose tolerance, and insulin sensitivity. Together, our findings reveal the possibility that phosphatidylation of mannose could be used as a dietary approach to prevent obesity-associated diseases via its enhanced mannose bioavailability.
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