Cytotoxic metabolites from the leaves of the mangrove Rhizophora apiculata
2022
Thao, Nguyen Phuong | Linh, Kieu Thi Phuong | Quan, Nguyen Huu | Trung, Vu Thanh | Binh, Pham Thanh | Cuong, Nguyen The | Nam, Nguyen Hoai | Van Thanh, Nguyen
One new 8,4’-oxyneolignan (1) and one new 7,8-dihydrobenzofuranone (2), together with twenty-one known compounds (3‒23) were isolated from the methanol extract of Rhizophora apiculata leaves. The structures of new compounds, as well as their absolute configuration, were determined by a combination of spectroscopic methods and quantum chemical calculations of NMR and ECD data. All isolated compounds were evaluated for their cytotoxicity, and only 2,6-dimethoxy-1,4-benzoquinone (8) exhibited inhibitory effects against SK-LU-1, HepG2, and MCF7 cells with IC₅₀ values in the range of 8.33–14.82 μM.
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