Terretonin D1, a new meroterpenoid from marine-derived Aspergillus terreus ML-44
2019
Wu, Chang-Jing | Cui, Xiang | Kjellgren, Björn | Yang, Mingsheng | Zhang, Yun-Xia | Liu, Xiao-Meng
A new meroterpenoid, named terretonin D1 (1), and three known ones, terretonin (2), terretonin A (3), and terretonin D (4), were isolated from marine-derived fungus Aspergillus terreus ML-44. The structure of 1 was elucidated by extensive spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and the absolute configuration was determined by X-ray crystallographic analysis. The anti-inflammation activity of 1–4 was preliminarily tested, and all of them weakly inhibited the nitric oxide (NO) production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS), with inhibitory rates of 22–34% at 50 μg/mL.
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