Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)
2010
Starks, Courtney M. | Williams, Russell B. | Goering, Matt G. | O’Neil-Johnson, Mark | Norman, Vanessa L. | Hu, Jin-Feng | Garo, Eliane | Hough, Grayson W. | Rice, Stephanie M. | Eldridge, Gary R.
Nine clerodane diterpenes, solidagoic acids C-I (1–7), cleroda-3,13(14)-dien-16,15:18,19-diolide (8) and cleroda-3,13(14)-dien-15,16:18,19-diolide (9) were isolated and characterised from the ethanol–ethyl acetate (1:1) extract of Solidago virgaurea. The structures were determined by NMR spectroscopic analysis. Several displayed moderate antibacterial activity against Staphylococcus aureus.
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