Mechanism of action of Clostridium perfringens enterotoxin
1980
McDonel, James L.
Clostridium perfringens-produced enterotoxin is responsible for one of the most common forms of food poisoning. Although little is known concerning the mechanism producing the associated symptoms, progress is being made; it is hoped that intensive research will provide an exact description on the systemic, organ, cellular, and molecular levels. Animal studies indicate that DNA, RNA, and protein synthesis are all affected by the enterotoxin within a period of 30 minutes. There is a yet unproved assumption that enterotoxin action also causes cell membrane damage. Binding studies show the enterotoxin does not bind with brain cells. Since perfringens enterotoxin inhibits glucose uptake, macromolecular synthesis, and energy metabolism, it appears to be in a different category from other enterotoxins.
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