Effect of ginseng total saponin on bovine adrenal tyrosine hydroxylase
1998
Kim, Hack-Seang | Zhang, Yong-he | Fang, Lian-Hua | Lee, Myung-Koo
Ginseng total saponin (GTS) can modulate dopaminergic activity at both presynaptic and postsynaptic dopamine receptors (Kimet al., 1998). The present study investigated the effect of GTS on the bovine adrenal tyrosine hydroxylase (TH), which catalyze L/tyrosine to DOP. GTS inhibited the bovine adrenal TH by 42.4, 51.5 and 55.3% at concentrations of 40, 80 and 100 μg/ml, respectively. The IC₅₀ value of GTS was 77.5 μg/ml. GTS exhibited noncompetitive inhibition with a substrate L-tyrosine. The Ki value was 155 μg/ml.
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