Toxicity of the fungal metabolite griseofulvin to Helicoverpa zea and Spodoptera frugiperda
1993
Dowd, Patrick F.
Griseofulvin is a fungal metabolite that can be considered a mycotoxin but is used pharmaceutically to treat topical fungal infections. It was found to be toxic to both the corn earworm. Helicoverpa zea Boddie, and the fall armyworm, Spodoptera frugiperda (J. E. Smith), at 250 ppm in diets. Its toxicity was enhanced by exposure to ultraviolet light, suggesting it can be photoactivated. Its toxicity was also enhanced by coincorporated δ-amino levulinic acid, suggesting it interferes with porphyrin synthesis in these insects. Differences in toxicity and rates of metabolism caused by coincorporated piperonyl butoxide suggested unspecific monooxygenases were relatively more important in griseofulvin activation in H. zea and detoxification in S. frugiperda.
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