Effect of Cisplatin Alone and in Combination with γ-Radiation on the Initiation of DNA Synthesis in Friend Leukemia Cells
2014
Ganeva, Roumiana L. | Tzvetkov, Lyuben M.
The effect of the anticancer drug cisplatin (alone and in combination with γ-radiation) on the initiation of DNA synthesis in Friend leukemia cells was studied. A method for isolation of DNA fractions containing the origins of replication was used. It was found that cisplatin decreased the rate of the initiation of DNA synthesis. The mild γ-radiation has previously been observed to inhibit the initiation of DNA synthesis. In the present investigation the combination of cisplatin and γ-radiation showed additive effects without synergism on the initiation of DNA biosynthesis.
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