Intra‐operative cisplatin for the treatment of canine extremity soft tissue sarcomas
2009
Havlicek, M. | Straw, R. S. | Langova, V. | Dernell, W. S.
Nineteen dogs with histologically confirmed soft tissue sarcomas of the extremities were treated with a combination of marginal surgery and intra‐operative chemotherapy in the form of cisplatin in a biodegradable implant delivery system (Atrigel®; Atrix Laboratories, Fort Collins, Co, USA). None of the dogs had evidence of metastasis at time of treatment. The median dose of cisplatin was 52.1 mg/m² (mean 55.4 mg/m², range 18.5–108.6 mg/m²). Wound complications were noted in 16 dogs (84.2%). Median follow‐up time was 874 days (mean 777 days, range 125–1463 days). Nine dogs (47.3%) were alive at the time of analysis. Local recurrence occurred in three dogs (16.6%). The time to recurrence was 214, 264 and 874 days.
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