Phytochemical profile and antiproliferative activity of human lymphocytes of Gomphrena virgata Mart. (Amaranthaceae)
2022
Marinho, Barbhara Mota | Fernandes, Débora Nunes | Chicoti, Mayara Zimmermann | Ribeiro, Giovane de Jesus Gomes | Almeida, Valéria Gomes de | Santos, Michaelle Geralda dos | Guimarães, Victor Hugo Dantas | Marchioretto, Maria Salete | Martins, Helen Rodrigues | de Melo, Gustavo Eustáquio Brito Alvim | Gregorio, Luiz Elidio
Gomphrena virgata Mart. popularly known as ‘Cangussu-branco’, is used in Brazilian folk medicine to treat inflammations and infections. This work aimed to carry out phytochemical analysis and evaluate the anti-inflammatory potential of Gomphrena virgata. In the phytochemical investigation, in addition to the presence of two ecdysteroids, 20 R-dihydroxyecdysone and 20-hydroxyecdysone, identified by HPLC-PDA-MS and NMR, 22 compounds were identified by GC-MS. In the cytotoxicity study, the aqueous extract of the roots of this species did not show in vitro toxicity of PBMCs in the concentrations of 250, 500 and 1000 µg/mL when analyzed by the trypan blue exclusion method. Also, it was effective in reducing lymphocyte proliferation, stimulated with the mitogen PHA, by 26.02%, 48.57% and 50.49% when compared to dexamethasone, respectively. In this work we present information about the phytochemicals of G. virgata, showing that the species is promising in obtaining compounds with medicinal potential mainly anti-inflammatory potential.
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