Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN³ Pincer Catalyst
2020
Hofmann, Natalie | Homberg, Leonard | Hultzsch, Kai C.
A straightforward and selective synthesis of 1,2,3,4-tetrahydroquinolines starting from 2-aminobenzyl alcohols and simple secondary alcohols is reported. This one-pot cascade reaction is based on the borrowing hydrogen methodology promoted by a manganese(I) PN³ pincer complex. The reaction selectively leads to 1,2,3,4-tetrahydroquinolines thanks to a targeted choice of base. This strategy provides an atom-efficient pathway with water as the only byproduct. In addition, no further reducing agents are required.
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