Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells
2020
Fadaeinasab, Mehran | Karimian, Hamed | Omar, Hanita | Taha, Hairin | khorasani, Arash | Banisalam, Behrooz | Aziz Ketuly, Kamal | Abdullah, Zanariah
One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC₅₀ value of 30.24 ± 0.75 µM. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile.
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