Inhibition of acetyl-coenzyme A carboxylase by the novel grass-selective herbicide 3-(2,4-dichlorophenyl)-perhydroindolizine-2,4-dione
1991
Babczinski, P. | Fischer, R.
The novel herbicidal compound 3-(2,4-dichlorophenyl)-perhydroindolizine-2,4-dione which is active as a pre- and post-emergence grass-selective herbicide is a new type of inhibitor of plant acetyl-coenzyme A carboxylase (ACCase; E.C. 6.4.1.2). This has been demonstrated by in-vitro experiments using isolated corn enzyme. Besides an I50 value of 4.7 micromolar under the assay conditions used, a mixed-type inhibitory activity on the enzyme is established. The compound is inactive on rat liver ACCase enzyme and shows decreased activity (pI50 less than 3.0) on the spinach enzyme.
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