New aspidosperma-type alkaloids from Tabernaemontana bovina
2022
Zhao, Xue | Du, Si-Yu | Liu, Jie | Liu, Jia-Ning | Jiang, Cheng-Shi | Zhu, Kong-Kai | Fang, Lei
Two new aspidosperma-type alkaloids, taberibogines C and D (1 and 2), along with three known ones (3–5), were isolated from the leaves of Tabernaemontana bovina. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and X-ray crystal diffraction. Alkaloids 1-2 exhibited moderate inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages.
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