Nickel-Catalyzed Remote C4–H Arylation of 8-Aminoquinolines
2019
Zhu, Longzhi | Sheng, Xinghao | Li, You | Lu, Dong | Qiu, Renhua | Kambe, Nobuaki
A useful and convenient method for C–H bond arylation of 8-aminoquinoline motifs on the remote C4 position was developed. This method shows good functional group tolerance toward various Grignard reagents and aminoquinoline via a nickel catalysis, giving the desired arylated products in good yields. The present method affords an efficient access to construct multisubstituted aminoquinolines.
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