Influence of dietary vitamin E on malondialdehyde levels in liver and adipose tissue and on glutathione peroxidase and reductase activities in liver and erythrocytes of lean and obese (ob/ob) mice
1979
To determine the effect of obesity on the dietary requirement for vitamin E, genetically obese mice (OM) and their lean littermates (LM) were assigned to casein-based diets supplemented with 0., 40, 80, or 320 ppm vitamin E (E) for 6 weeks. At the end of this period, mice were decapitated, and erythrocytes, liver, and adipose tissue taken for analysis. Hepatic and adipose tissue fat soluble antioxidant (FSAO) concentration increased with increasing dietary E. On the basis of response in FSAO, adipose malondialdehyde (MDA), and adipose fatty acid (FA), OM appear to have a higher requirement for E than their lean counterparts.
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