Effect of a genetic polymorphism in SREBP1 on fatty acid composition and related gene expression in subcutaneous fat tissue of beef cattle breeds
2021
Gamarra, David | Aldai, Noelia | Arakawa, Aisaku | de Pancorbo, Marian M. | Taniguchi, Masaaki
Sterol regulatory element‐binding factor 1 (SREBP1) plays an important role in the lipogenesis which affects fatty acid (FA) composition in backfat and consequently influences beef nutritional quality. This study analyzed the association of 84 bp‐indel, both short (S) and long (L) alleles in intron 5 of SREBP1, with FA composition and gene expression of SREBP1 in backfat of northern Spanish beef breeds (Pirenaica, Salers and Holstein‐Friesian). Phylogenetic analysis suggests that 84 bp‐indel of ruminants is a highly conserved region compared with those in the full‐length sequence of intron 5 or mRNA of SREBP1 among species. Overall, higher content of polyunsaturated FAs was observed in SL genotype compared to LL genotype of 84 bp‐Indel (p < .05). In particular, in Pirenaica, SL genotype was associated with a higher content of stearic (18:0), α‐linolenic (18:3n‐3) acid, and total n‐3 content (p < .05). However, the gene expression of SREBP1 did not differ among genotypes of 84 bp‐Indel (p > .05).
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por National Agricultural Library