Activation of Nrf2/Keap1 signaling and autophagy induction against oxidative stress in heart in iron deficiency
2015
Inoue, Hirofumi | Kobayashi, Ken'ichi | Ndong, Moussa | Yamamoto, Yūji | Katsumata, Shin-Ichi | Suzuki, Kazuharu | Uehara, Mariko
We investigated the effects of dietary iron deficiency on the redox system in the heart. Dietary iron deficiency increased heart weight and accumulation of carbonylated proteins. However, expression levels of heme oxygenase-1 and LC3-II, an antioxidant enzyme and an autophagic marker, respectively, in iron-deficient mice were upregulated compared to the control group, resulting in a surrogate phenomenon against oxidative stress.
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